Open AccessPlasma oxidative stress and inflammatory biomarkers are associated with the sizes of the left atrium and pulmonary vein in atrial fibrillation patients
Author(s) -
Li Jinyi,
He Yan,
Ke Honghong,
Jin Yu,
Jiang Zhiyuan,
Zhong Guoqiang
Publication year - 2017
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.22633
Subject(s) - medicine , atrial fibrillation , oxidative stress , cardiology , pulmonary vein , pathogenesis , gastroenterology
Background Oxidative stress and inflammatory processes are responsible for the pathogenesis of AF, but their relationship with the sizes of the LA and PVs in AF patients remains unclear. Hypothesis Oxidative stress and inflammatory processes are associated with the sizes of the LA and PVs in AF patients. Methods 82 AF patients were compared to 30 control patients by using a case‐control study design. Oxidative stress, inflammatory biomarkers and the sizes of the LA and PVs were detected. Results (1) Hs‐CRP, IL‐6, IL‐8, TNF‐α, MDA and ox‐LDL were higher, and SOD was lower in AF patients than in control patients. Hs‐CRP, MDA and ox‐LDL were higher in permanent AF patients than in paroxysmal and persistent AF patients. (2) CsA of LSPV, RSPV, RIPV, LAA and LAV were statistically higher in AF patients than in control patients. CsA of RSPV, LSPV, LIPV and LAV were higher in permanent AF patients than in paroxysmal and persistent AF patients. (3) In the AF group, hs‐CRP and TNF‐α were positively correlated with LAV; MDA was positively correlated with CsA of LAA, LSPV and LAV; SOD was passively correlated with CsA of LAA and LAV; ox‐LDL was positively correlated with CsA of LAA and LAV. Multivariate logistic regression analysis showed hs‐CRP, ox‐LDL, RSPV CsA, LIPV CsA and LAV were associated with AF. Conclusions Oxidative stress, inflammatory biomarkers and the sizes of the LA and PVs were significantly increased in AF patients. Hs‐CRP, ox‐LDL, RSPV CsA, LIPV CsA and LAV were associated with AF persistence.