z-logo
open-access-imgOpen Access
The Obesity Paradox in Patients Undergoing Transcatheter Aortic Valve Implantation
Author(s) -
Konigstein Maayan,
Havakuk Ofer,
Arbel Yaron,
Finkelstein Ariel,
BenAssa Eyal,
Leshem Rubinow Eran,
Abramowitz Yigal,
Keren Gad,
Banai Shmuel
Publication year - 2015
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.22355
Subject(s) - medicine , overweight , underweight , body mass index , hazard ratio , obesity , obesity paradox , confidence interval , population , cardiology , incidence (geometry) , risk factor , surgery , physics , environmental health , optics
Background Obesity is a major risk factor for cardiovascular morbidity and mortality. A considerable number of studies, however, showed better outcomes for overweight patients undergoing cardiovascular interventions—the so called obesity paradox . Hypothesis Increased body mass index ( BMI ) is independently associated with improved survival following transcatheter aortic valve implantation ( TAVI ). Methods We analyzed the data of 409 consecutive patients undergoing TAVI in our medical center. Patients were categorized into 4 groups according to BMI : underweight (≤18.4 kg/m 2 ), normal weight (18.5–24.9 kg/m 2 ), overweight (25–29.9 kg/m 2 ), and obese (≥30 kg/m 2 ). Procedure‐related complications were recorded, as well as 30‐day and 1‐year all‐cause mortality rates. Results Obese patients had a higher prevalence of comorbidities and higher incidence of vascular complications compared with the normal‐weight patients (16% vs 7%, P = 0.013). Nevertheless, 30‐day mortality was similar among the groups, whereas 1‐year mortality was lower among the overweight and obese patients ( BMI >25) ( P = 0.038). After adjusting for differences in baseline characteristics, increase in BMI was found to be independently associated with improved survival following TAVI (hazard ratio: 0.94, confidence interval: 0.89‐0.99, P = 0.043). Conclusions In our single‐center study, obesity and overweight were independently associated with better outcome, supporting the obesity paradox in the TAVI population.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here