Open AccessImpact of Adverse Left Ventricular Remodeling on Sudden Cardiac Death in Patients With Hypertrophic Cardiomyopathy
Author(s) -
Vriesendorp Pieter A.,
Schinkel Arend F.L.,
de Groot Natasja M. S.,
van Domburg Ron T.,
ten Cate Folkert J.,
Michels Michelle
Publication year - 2014
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.22293
Subject(s) - medicine , cardiology , hypertrophic cardiomyopathy , odds ratio , ventricular remodeling , sudden cardiac death , atrial fibrillation , heart failure , adverse effect , diastole , sudden death , cardiomyopathy , confidence interval , population , blood pressure , environmental health
Background Adverse left ventricular ( LV ) remodeling predicts heart failure symptoms and overt LV dysfunction in patients with hypertrophic cardiomyopathy ( HCM ), but its influence on the occurrence of sudden cardiac death ( SCD ) is unknown. The aim of this study was to investigate the effect of adverse LV remodeling on SCD risk in patients with HCM . Hypothesis Adverse LV remodeling increases SCD in HCM patients. Methods This study included 41 patients with HCM who experienced SCD ; each case was matched with 3 controls based on age, gender, and time of first contact. In this population of 164 patients, predictors of SCD were identified using univariable and multivariable logistic regression and expressed as odds ratio ( OR ) with 95% confidence interval ( CI ). Results Baseline characteristics, such as New York Heart Association ( NYHA ) class, systolic and diastolic left ventricular function, left ventricular wall thickness, left atrial size, atrial fibrillation, and established risk factors for SCD were similar in cases and controls. Independent predictors of SCD during follow‐up (median follow‐up, 7.7 ± 6.5 years) were: increase in NYHA class ( OR : 8.7 [95% CI : 2.5‐30.5], P = 0.001), decrease of fractional shortening (per % decrease, OR : 1.09 [95% CI : 1.03‐1.14], P = 0.001), and decrease of diastolic function ( OR : 3.5 [95% CI : 1.2‐10.2], P = 0.02). Conclusions This study shows that SCD risk in HCM increases when adverse remodeling occurs. Because cases and controls were similar at baseline, these findings emphasize the importance of vigilant follow‐up of HCM patients and could aid clinical decision making concerning implantable cardioverter‐defibrillator implantation, especially in patients with moderate risk for SCD .