z-logo
open-access-imgOpen Access
Adiponectin Levels Are Elevated in Patients With Pulmonary Arterial Hypertension
Author(s) -
Santos Mário,
Reis Abílio,
Gonçalves Fabienne,
FerreiraPinto Manuel J.,
Cabral Sofia,
Torres Severo,
LeiteMoreira Adelino F.,
HenriquesCoelho Tiago
Publication year - 2014
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.22210
Subject(s) - medicine , adiponectin , cardiology , pulmonary hypertension , obesity , insulin resistance
Background In addition to insulin‐sensitizing effects, adiponectin influences several mechanisms involved in pulmonary arterial hypertension ( PAH ) pathobiology. Insulin resistance has been associated with PAH , and elevated adiponectin levels have been described in left heart failure ( HF ) as a response to the increased metabolic stress. No studies have been performed in right HF or PAH patients. Hypothesis Compared to healthy controls, PAH patients have a different plasma adipocytokine profile, higher insulin resistance, and higher inflammatory systemic activation. Methods A case–control study was conducted in PAH patients individually matched for sex, age, and body mass index. We characterized the clinical features, functional status (6‐minute walking test), and hemodynamic profile of cases (n = 25). We measured insulin resistance (homeostasis model assessment and high‐density lipoprotein/triglycerides ratio), inflammatory systemic activation (high‐sensitivity C‐reactive protein), and plasma adipocytokine profile (adiponectin, leptin, visfatin, and resistin) in cases and controls. Results PAH patients had significantly higher adiponectin levels than controls (12.4 ± 6.9 vs 8.1 ± 4.5 µg/ mL ; P < 0.05) and higher high‐sensitivity C‐reactive protein (2.96 ± 3.2 vs 1.08 ± 1.1; P < 0.05). No statistically significant differences were found in plasma levels of leptin, visfatin, and resistin between groups. Conclusions Adiponectin levels are increased in PAH patients compared to controls. Further studies are needed to study the potential role of adiponectin as a PAH biomarker.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here