Open AccessThe Effects of Continuous Positive Airways Pressure Therapy on Cardiovascular End Points in Patients With Sleep‐Disordered Breathing and Heart Failure: A Meta‐Analysis of Randomized Controlled Trials
Author(s) -
Aggarwal Saurabh,
Nadeem Rashid,
Loomba Rohit S.,
Nida Mahwish,
Vieira Dorice
Publication year - 2014
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.22201
Subject(s) - medicine , ejection fraction , cardiology , heart failure , blood pressure , continuous positive airway pressure , randomized controlled trial , positive airway pressure , heart rate , meta analysis , odds ratio , confidence interval , anesthesia , obstructive sleep apnea
In patients with sleep‐disordered breathing and heart failure, continuous positive airway pressure has been found to be associated with an improvement in cardiovascular end points. We conducted a systematic review of the current literature and a meta‐analysis to pool data from 15 published randomized controlled trials. End points analyzed were left ventricular ejection fraction, diastolic blood pressure, systolic blood pressure, heart rate, and mortality. A fixed effects model was used for end points demonstrating homogeneity among included studies, whereas a random effects model was used for end points demonstrating heterogeneity among included studies. A significant improvement in left ventricular ejection fraction was noted with continuous positive airway pressure (mean difference, 5.05%; 95% confidence interval [ CI ]: 3.72 to 6.38), diastolic blood pressure (mean difference, −1.67; 95% CI : −3.09 to −0.25), and heart rate (mean difference, −5.92; 95% CI : −10.12 to −1.72). No significant changes in mortality (odds ratio, 0.63; 95% CI : 0.40 to 1.00) and systolic blood pressure were noted (mean difference, −6.35; 95% CI : −16.11 to 2.41). The analysis also revealed the need for additional studies to clarify the associations noted and the presence of publication bias with small studies with a paucity of small studies with negative results. In this meta‐analysis, treatment with continuous positive airways pressure was associated with improvements in ejection fraction, diastolic blood pressure, and heart rate in patients with sleep‐disordered breathing and congestive heart failure.