Open AccessImprovement of Arterial Stiffness in the Transition From Acute Decompensated Heart Failure to Chronic Compensated Heart Failure
Author(s) -
Kim DongBin,
Baek Sang Hong,
Jang Sung Won,
Her SungHo,
Shin DongIl,
Park Chan Seok,
Park Hoon Joon,
Kim Pum Joon,
Jung Hae Ok,
Seung Ki Bae
Publication year - 2013
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.22127
Subject(s) - medicine , heart failure , acute decompensated heart failure , cardiology , arterial stiffness , intensive care medicine , blood pressure
Background Pulse wave velocity ( PWV ) is a well‐established marker for aortic stiffness and may be a prognostic factor in heart failure (HF). This study investigates whether PWV changes as patients transition from acute decompensated heart failure ( ADHF ) to chronic compensated heart failure (CCHF). Hypothesis Arterial stiffness is related with the development of HF. Methods Regional PWV was prospectively measured using noninvasive applanation tonometry in consecutive ADHF patients (n = 55). PWV measurements of 45 patients were taken at admission and 3‐month follow‐up (F/U). Results Central and upper‐extremity PWV , but not lower‐extremity PWVs , were found to have improved after 3 months compared with the admission PWV (central: 8.73 ± 1.17 vs 8.39 ± 0.99 m/s, P = 0.018; upper extremity: 8.59 ± 0.84 vs 8.33 ± 0.82 m/s, P = 0.028). Multivariate logistic regression analyses revealed that low‐density lipoprotein cholesterol was significantly associated with the change of PWV in HF (odds ratio: 1.037, 95% confidence interval: 1.003‐1.071, P = 0.030). In preserved left ventricular ejection fraction patients (n = 26) and ischemic patients (n = 31), central and upper‐extremity PWVs improved over the admission PWV at 3‐month F/U. Conclusions The present results indicate that central and upper‐extremity PWVs , but not lower‐extremity PWV , are increased in ADHF and improve as patients transition from ADHF to CCHF.