Association Between Tp‐e/QT Ratio and Prognosis in Patients Undergoing Primary Percutaneous Coronary Intervention for ST‐Segment Elevation Myocardial Infarction

Background: Both the Tpeak‐Tend interval (Tp‐e) and the Tp‐e/QT ratio have been linked to increased risk for arrhythmia. Patient Tp‐e/QT ratios were investigated prior to primary percutaneous coronary intervention (pPCI) in patients with ST‐segment elevation myocardial infarction (STEMI). Hypothesis: Tp‐e/QT ratio maybe asscioated with the prognosis in patients with ST‐segment elevation. Methods: A total of 338 patients (N = 338) with STEMI treated by pPCI were included. The Tp‐e and Tp‐e/QT ratio were determined using electrocardiograms in the subjects exhibiting ST‐segment elevation. Results: The Tp‐e/QT ratio was correlated with both short‐ and long‐term outcomes. Analysis of the receiver operating characteristic curve demonstrated that the optimal cutoff value for outcome prediction was a Tp‐e/QT ratio of 0.29. Of the 388 patients enrolled, 115 (34.0%) exhibited a Tp‐e/QT ratio ≥0.29. Patients with a Tp‐e/QT ratio ≥0.29 showed elevated rates of both in‐hospital death (21.9% vs 2.3%; P < 0.001) and main adverse cardiac events (MACE) (48.1% vs 15.3%; P < 0.005). After discharge, Tp‐e/QT ratios ≥0.29 remained an independent predictor of all‐cause death (35.5% vs 5.2%, P < 0.001) and cardiac death (32.3% vs 2.6%, P < 0.001). Conclusions: The Tp‐e/QT ratio may serve as a prognostic predictor of adverse outcomes after successful pPCI treatment in STEMI patients. Clin. Cardiol. 2012 doi: 10.1002/clc.22022 This work was supported by grants from the Henan Provincial People's Hospital. The authors have no other funding, financial relationships, or conflicts of interest to disclose.