Open AccessPreoperative Treatment With an Angiotensin‐Converting Enzyme Inhibitor or an Angiotensin Receptor Blocker Has No Beneficial Effect on the Development of New‐Onset Atrial Fibrillation After Off‐Pump Coronary Artery Bypass Graft Surgery
Author(s) -
Chin JiHyun,
Lee EunHo,
Son Hyo Jung,
Kim WookJong,
Choi DaeKee,
Park SooKyoung,
Sim JiYeon,
Choi InCheol,
Hahm KyungDon
Publication year - 2012
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.20991
Subject(s) - medicine , atrial fibrillation , odds ratio , cardiology , angiotensin receptor , incidence (geometry) , angiotensin converting enzyme , confidence interval , retrospective cohort study , ace inhibitor , angiotensin ii , blood pressure , physics , optics
Background: The present study investigated whether preoperative angiotensin‐converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) use affected the incidence of postoperative atrial fibrillation (POAF) in patients undergoing off‐pump coronary artery bypass graft (OPCAB). Hypothesis: Preoperative use of ACEI or ARB was related to POAF in patients undergoing OPCAB. Methods: This retrospective, observational, cohort study involved 1050 patients who underwent OPCAB from January 2006 to December 2009. Results: ACEI or ARB, ACEI alone, and ARB alone did not exert beneficial effect on the occurrence of POAF, and ACEI or ARB use was rather associated with an increased incidence of POAF (ACEI or ARB: odds ratio [OR]: 1.66, 95% confidence interval [CI]: 1.04–2.62, P = 0.03; ACEI alone: OR: 1.30, 95% CI: 0.57–2.97, P = 0.53; ARB alone: OR: 1.57, 95% CI: 0.93–2.64, P = 0.09). Conclusions: ACEI or ARB, ACEI alone, and ARB alone did not favorably influence the occurrence of POAF in patients undergoing OPCAB. © 2011 Wiley Periodicals, Inc. The authors have no funding, financial relationships, or conflicts of interest to disclose.