Open AccessRisk Factors of Cardiac Troponin T Elevation in Patients with Stable Coronary Artery Disease After Elective Coronary Drug‐Eluting Stent Implantation
Author(s) -
Chen ZhangWei,
Qian JuYing,
Ma JianYing,
Ge Lei,
Ge JunBo
Publication year - 2011
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.20973
Subject(s) - medicine , cardiology , coronary artery disease , stent , univariate analysis , troponin i , drug eluting stent , troponin , troponin t , percutaneous coronary intervention , restenosis , multivariate analysis , myocardial infarction
Background: Cardiac troponin T elevation after coronary intervention has been demonstrated to be associated with the prognosis of coronary artery disease (CAD). However, there were few studies about comprehensive risk factors analysis of troponin T elevation after elective drug‐eluting stent (DES) implantation. Hypothesis: The prognosis of CAD after coronary interventions was associated with clinical and procedural risk factors of CAD, such as age, hypertension, severity extent of CAD and so on. Methods: From March to December in 2010, patients with stable CAD were admitted for elective coronary intervention in our hospital. They were divided into an elevated troponin T group and a normal troponin T group by postprocedural troponin T. Clinical factors, laboratory‐test factors, and angiographic factors (such as gender, age, cholesterol, Gensini score, and others) were analyzed. Results: A total of 209 patients with an average age of 64.0 ± 9.9 years were enrolled in the study: 70 patients with elevated troponin T (≥0.03 ng/mL) after DES implantation and 139 patients with normal troponin T (<0.03 ng/mL). After univariate analysis, we found that age, hypertension, total cholesterol, low density lipoprotein‐cholesterol (LDL‐C), Gensini score, number of stenosed vessels, and total implanted stents were associated with postprocedural troponin T elevation. According to the results of multivariate analysis, we found that age, total cholesterol, number of stenosed vessels, and number of implanted stents were independent risk factors of postprocedural troponin T elevation. Conclusions: Age, serum total cholesterol, number of stenosed vessels, and number of implanted stents could be independent risk factors of troponin T elevation after elective DES implantation. © 2011 Wiley Periodicals, Inc. Z. Chen and J. Qian contributed equally to the article. This study was supported by grants from the National Natural Science Foundation of China (30671998 and30901383). The authors have no funding, financial relationships, or conflicts of interest to disclose.