Open AccessIntercellular Adhesion Molecule‐1 E469K Gene Polymorphism and Coronary Artery Disease in the Chinese Population: A Meta‐Analysis Involving 3065 Subjects
Author(s) -
Yanyan Li
Publication year - 2012
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.20972
Subject(s) - coronary artery disease , odds ratio , allele , meta analysis , medicine , population , gene polymorphism , allele frequency , genetics , confidence interval , polymorphism (computer science) , gene , biology , environmental health
Abstract Background: The intercellular adhesion molecule‐1 ( ICAM‐1 ) E469K gene polymorphism has been implicated in increased coronary artery disease (CAD) susceptibility, but the individual study results are still controversial. Hypothesis: The ICAM‐1 E469K gene polymorphism may be associated with CAD risk. Methods: The current meta‐analysis involving 3065 subjects and 11 separate studies was conducted to explore the relationship between the ICAM‐1 E469K gene polymorphism and CAD in the Chinese population. The pooled odds ratio (ORs) for the distribution of K allele frequency of ICAM‐1 E469K gene and its corresponding 95% confidence interval (CI) was assessed by random effect model. Results: The distribution of the K allele frequency was 0.67 for the CAD group and 0.60 for the control group. The pooled OR for the distribution of the K allele frequency of the ICAM‐1 E469K gene was 1.32 (95% CI, 1.02–1.72; P heterogeneity < 0.00001; inconsistency index I 2 = 81.8%). The association between the ICAM‐1 E469K gene polymorphism and CAD in the Chinese population was significant ( P = 0.04). Conclusions: In the Chinese population, the distribution of the K allele frequency of the ICAM‐1 E469K gene was indicated to be associated with CAD risk. The K allele of the ICAM‐1 E469K gene might predispose to the CAD susceptibility. © 2011 Wiley Periodicals, Inc. This work was funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD). The author has no other funding, financial relationships, or conflicts of interest to disclose.