Open AccessRole of CA‐125 in Identification of Right Ventricular Failure in Chronic Obstructive Pulmonary Disease
Author(s) -
Yilmaz Mehmet Birhan,
Zorlu Ali,
Dogan Omer Tamer,
Karahan Oguz,
Tandogan Izzet,
Akkurt Ibrahim
Publication year - 2011
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.20868
Subject(s) - medicine , copd , cardiology , heart failure , exacerbation , biomarker , pulmonary artery , pulmonary disease , biochemistry , chemistry
Background: Chronic obstructive pulmonary disease (COPD) is a progressive and debilitating disease. Cor pulmonale, characterized by right ventricular (RV) failure, can severely influence prognosis in these patients. Hence, early recognition might be important for tailoring therapy. An old biomarker, CA‐125, seems to be associated with the right heart. We aimed to show the relationship between CA‐125 levels and RV failure in patients with COPD. Hypothesis: CA‐125 might be a useful biomarker in identification of RV failure in patients with COPD. Methods: Forty patients with recent exacerbation of COPD were enrolled into the study. Another 40 age‐ and sex‐matched individuals were enrolled for comparison. Levels of CA‐125 were measured in the patients during the hospital stay. The COPD patients underwent echocardiographic study on the same day. Right‐ventricular parameters were evaluated, and RV failure was identified via transthoracic echocardiography. Results: Patients with COPD had significantly higher CA‐125 levels compared with controls (median 33.94 U/mL vs 9.76 U/mL, respectively; P < 0.001). Levels of CA‐125 were correlated with systolic pulmonary artery pressure ( r = 0.550, P < 0.001), tricuspid annular plane systolic excursion ( r = − 0.496, P = 0.001), and tricuspid lateral annulus S velocity ( r = − 0.549, P = 0.002). High CA‐125 levels, obtained in hospitalized patients with COPD before echocardiography, enabled identification of RV failure with a sensitivity of 89.5% and specificity of 85.7%. Conclusions: The CA‐125 biomarker can be used to identify COPD patients with RV failure. © 2011 Wiley Periodicals, Inc. The authors have no funding, financial relationships, or conflicts of interest to disclose.