Open AccessGrowth Differentiation Factor 15 and Coronary Collateral Formation
Author(s) -
Sun Tao,
Huang Yanbo,
Phillips M. Ian,
Luo Xinping,
Zhu Jun,
Shi Haiming,
Li Jian
Publication year - 2010
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.20698
Subject(s) - medicine , gdf15 , cardiology , collateral circulation , coronary artery disease , asymmetric dimethylarginine , collateral , coronary angiography , transforming growth factor , artery , myocardial infarction , arginine , biochemistry , chemistry , amino acid , finance , economics
Background The coronary collateral circulation can reduce sudden cardiac death,myocardial cell loss,and infarct size.Growth differentiation factor 15(GDF‐15),a member of the transforming growth factor‐β (TGF‐β) superfamily,has been reported to have a prognostic predicting value in coronary artery disease. Hypothesis GDF‐15 can be related with the extent of collateral formation. Objective Growth differentiation factor 15 (GDF‐15), a member of the transforming growth factor‐β (TGF‐β) superfamily, has been reported to have a prognostic predicting value in coronary artery disease. We sought to investigate whether GDF‐15 is related to coronary collateral development in patients with coronary heart disease. Methods A cross‐sectional study was performed in 201 patients, who were admitted for selective coronary angiography. Patients were divided into 3 groups based on Rentrop's classification of coronary collaterals. Group 1: patients with coronary collateral presence, which was defined by Rentrop's grade 1–3 collateral development. Group 2: patients with grade 0 collateral development. Group 3: control group were patients with a normal coronary angiogram. The levels of plasma GDF‐15, asymmetric dimethylarginine (ADMA), and soluble Fms‐related tyrosine kinase‐1 (sFLT‐1) were compared among the 3 groups. Results There were significant statistical differences in plasma sFLT‐1, ADMA, and GDF‐15 concentrations among the different collateral groups. The correlations between Rentrop's grade and the cytokines were significant. A positive correlation was found between Rentrop's grade and GDF‐15 ( r = 0.187, P < 0.05). The correlations between the levels of plasma sFLT‐1, ADMA, and Rentrop's grade were significant, with the correlation coefficient of r = 0.181, P < 0.05 (sFLT‐1) and r = − 0.646, P < 0.001 (ADMA), respectively. Conclusions Our findings suggest that GDF‐15 levels increase with the extent of collateral formation. In that case, the patients with a higher level of GDF‐15 may predict more severe coronary stenosis, which has a higher probability to develop collaterals. Copyright © 2009 Wiley Periodicals, Inc.