Open AccessHypoadiponectinemia Is Associated With Prehypertension in Obese Individuals of Multiethnic Origin
Author(s) -
Celoria Bruno M.J.,
Genelhu Virginia A.,
Pimentel Duarte Stenio Fernando,
Delfraro Paula A.S.,
Francischetti Emilio A.
Publication year - 2010
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.20657
Subject(s) - adiponectin , medicine , prehypertension , adipokine , endocrinology , blood pressure , insulin resistance , logistic regression , obesity
Background Considering that prehypertension is associated with an increase in cardiovascular risk, hypoadiponectinemia seems to be a predictor of hypertension. Hypothesis This study investigated whether adiponectin plasma levels are affected in Brazilian obese prehypertensives compared with those in normotensives and hypertensives. Methods The study involved 96 multiethnic obese subjects (mean age = 42.8–11.9 years; BMI = 35.7–7.3 kg/m 2 ). Fasting plasma adiponectin and serum insulin were determined by radioimmunoassay. Insulin resistance was estimated by HOMA‐IR. Blood pressure was recorded using a calibrated automated sphygmomanometer. Results Adiponectin concentrations were significantly lower in prehypertensives compared with those in normotensives, but hypertensives exhibited the lowest adiponectin concentrations of all. Regarding the values of HOMA‐IR, both prehypertensives and hypertensives were significantly more insulin resistant when compared with normotensives. When normotensives and prehypertensives were classified according to the 50th percentile of adiponectin (≤ vs > 6.5 mg/ml) a logistic regression was performed to estimate the association of this adipokine with hypertension, the lower the plasma adiponectin values, the greater the association. A multivariate linear regression analysis adjusted for cardiometabolic factors showed that systolic blood pressure increased by 1.612 mm Hg for 1 µg/mL reduction in adiponectin plasma levels (P < 0.01). Conclusion Our findings have shown that hypoadiponectinemia is associated with prehypertension in obese individuals of multiethnic origin. Copyright © 2010 Wiley Periodicals, Inc.