Open AccessPrevention of Contrast‐induced Nephropathy: A Single Center Randomized Study
Author(s) -
Castini Diego,
Lucreziotti Stefano,
Bosotti Laura,
Salerno Uriarte Diego,
Sponzilli Carlo,
Verzoni Alessandro,
Lombardi Federico
Publication year - 2010
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.20576
Subject(s) - medicine , contrast induced nephropathy , saline , creatinine , nephropathy , renal function , percutaneous coronary intervention , urology , clinical endpoint , sodium bicarbonate , nephrotoxicity , acute kidney injury , anesthesia , surgery , randomized controlled trial , kidney , myocardial infarction , endocrinology , diabetes mellitus , chemistry
Abstract Background Contrast‐induced nephropathy (CIN) is the third cause of acute deterioration of renal function in hospitalized patients. Hypothesis The purpose of the study was to compare the efficacy of saline infusion, saline infusion plus N‐acetylcysteine (NAC), and sodium bicarbonate (SB) infusion to prevent CIN in patients undergoing coronary angiography and/or percutaneous coronary intervention. Methods We prospectively studied 156 patients with a baseline creatinine level ≥ 1.2 mg/dL. The primary endpoint was the development of CIN, defined as an increase in serum creatinine concentration ≥ 25% over the baseline value within 5 days from contrast exposure. Results Contrast‐induced nephropathy developed in 23 patients (14.7%). Incidence of the primary endpoint was similar in the 3 groups of treatment, occurring in 7 patients (14%) in the saline infusion group, in 9 (17%) in the saline infusion plus NAC group, and in 7 (14%) in the SB infusion group. Conclusions Our findings suggest that neither the addition of NAC nor the administration of SB add further benefit in CIN prevention, compared to standard hydration with isotonic saline infusion. Copyright © 2009 Wiley Periodicals, Inc.