Open AccessClinical Estimation of Infarct Size by 201 Thallium Perfusion Scintigraphy and by Creatine Kinase‐MB in Early Myocardial Infarction
Author(s) -
FLETCHER J. W.,
RAO P. S.,
WITZTUM K. F.,
HAMILTON W. P.,
DONATI R. M.,
MUELLER H. S.
Publication year - 1980
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.1980.3.2.111
Subject(s) - medicine , creatine kinase , myocardial infarction , scintigraphy , thallium , perfusion , cardiology , infarction , nuclear medicine , radiology , inorganic chemistry , chemistry
201 Thallium ( 2011 Tl) perfusion scintigraphy was performed in 22 patients with first acute transmural myocardial infarction within the initial 12 h after onset of symptoms. The size of the abnormally perfused area on 201 Tl images was estimated by visual analysis and by a computer‐assisted technique. 201 Tl values for infarct size were compared to a biochemical estimate of infarct size using the cardiac specific isoenzyme creatine kinase‐MB (CK‐MB) and total creatine kinase (CK). Estimates of myocardial damage obtained from the visual and computer‐assisted analysis of the 201 Tl images showed a statistically significant correlation with the enzymatic estimates of infarct size. These results suggest that quantitative evaluation of 201 Tl image defects may provide useful information regarding the degree of myocardial damage in the very early stages of acute infarction before biochemical estimates of infarct size are available, and that sequential imaging with 201 TI might provide an independent method of monitoring evolutionary changes in myocardial damage.