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A likelihood ratio test for goodness‐of‐fit of recessive and dominant models for case–control studies
Author(s) -
Qian Meng,
Shao Yongzhao
Publication year - 2013
Publication title -
canadian journal of statistics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.804
H-Index - 51
eISSN - 1708-945X
pISSN - 0319-5724
DOI - 10.1002/cjs.11171
Subject(s) - goodness of fit , likelihood ratio test , statistics , test statistic , econometrics , null hypothesis , genetic model , statistic , score test , population , null distribution , statistical hypothesis testing , type i and type ii errors , mathematics , demography , biology , genetics , sociology , gene
Testing goodness‐of‐fit of commonly used genetic models is of critical importance in many applications including association studies and testing for departure from Hardy–Weinberg equilibrium. Case–control design has become widely used in population genetics and genetic epidemiology, thus it is of interest to develop powerful goodness‐of‐fit tests for genetic models using case–control data. This paper develops a likelihood ratio test (LRT) for testing recessive and dominant models for case–control studies. The LRT statistic has a closed‐form formula with a simple $\chi^{2}(1)$ null asymptotic distribution, thus its implementation is easy even for genome‐wide association studies. Moreover, it has the same power and optimality as when the disease prevalence is known in the population. The Canadian Journal of Statistics 41: 341–352; 2013 © 2013 Statistical Society of Canada