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A functional marked point process model for lupus data
Author(s) -
Fok Carlotta Ching Ting,
Ramsay James O.,
Abrahamowicz Michal,
Fortin Paul
Publication year - 2012
Publication title -
canadian journal of statistics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.804
H-Index - 51
eISSN - 1708-945X
pISSN - 0319-5724
DOI - 10.1002/cjs.11136
Subject(s) - point process , systemic lupus erythematosus , functional data analysis , point (geometry) , process (computing) , statistics , statistical model , flare , function (biology) , computer science , econometrics , medicine , mathematics , engineering , biology , geometry , disease , evolutionary biology , aerospace engineering , operating system
Abstract Modelling for marked point processes is an important problem, but has received remarkably little attention in the statistical literature. The authors developed a marked point process model that incorporates the use of functional data analysis in a joint estimation of the frequency function of the point process and the intensity of the mark, with application to data from 22 lupus patients consisting of times of flares in symptom severity combined with a quantitative assessment of the severity. The data indicate that a rapid decrease in drug dose is significantly associated with a decrease in flare frequency. Experiments with simulated data designed to model the actual data further support this conclusion. The Canadian Journal of Statistics 40: 517–529; 2012 © 2012 Statistical Society of Canada