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Publication year - 2021
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202190062
Subject(s) - chemistry , aldehyde , cover (algebra) , substrate (aquarium) , group (periodic table) , catalysis , combinatorial chemistry , organic chemistry , mechanical engineering , engineering , oceanography , geology
The cover picture shows ethyl bromodifluoroacetate directly reacts with azaindole without transition metal catalysis to produce a difluoromethyl protected 5‐aldehyde group product in one step. It is worth mentioning that the reacted aldehyde group is only formed at the 5 position. In addition, this method has good substrate applicability and functional group tolerance. Finally, the author also carried out some mechanism auxiliary experiments, which confirmed that the aldehyde‐based carbon comes from ethyl bromodifluoroacetate. More details are discussed in the article by Li et al . on page 1477–1482.