Premium
Inside Cover Picture
Publication year - 2021
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202190044
Subject(s) - chemistry , moiety , intramolecular force , sulfur , combinatorial chemistry , cover (algebra) , stereochemistry , organic chemistry , mechanical engineering , engineering
This work describes a novel protocol for the synthesis of the biologically interesting 3‐methylthio‐benzo[ b ]furans/benzo[ b ]thiophenes via intramolecular cyclization of 2‐alkynylanisoles/sulfides mediated by DMSO and SOCl 2 . The readily available, cheap and “greener” DMSO can be used as sulfur source to introduce the biologically interesting methylthio group into the two important heterocyclic skeletons. Furthermore, DMSO can also be replaced with DMSO‐ d 6 , enabling the incorporation of the SCD 3 moiety of DMSO‐ d 6 to the 3‐position of the heterocyclic frameworks. More details are discussed in the article by Du et al . on page 887—895.