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Publication year - 2021
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202190016
Subject(s) - chemistry , ring (chemistry) , cover (algebra) , combinatorial chemistry , tetrahydroisoquinoline , catalysis , palladium , copper , stereochemistry , organic chemistry , mechanical engineering , engineering
A copper‐catalyzed aerobic oxidative ring expansion reaction of isatins with 1,2,3,4‐tetrahydroisoquinoline for the synthesis of tetracyclic quinazolinones has been developed. The capacity of the resultant 5 H ‐isoquinolino[1,2‐ b ]quinazolin‐8(6 H )‐one for a range of palladium‐catalyzed directing C—H activation has been further demonstrated, thus giving a broader access to diverse tetracyclic quinazolinones. More details are discussed in the article by Xiao and Deng et al . on page 87—92.