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A Facile Construction of Bisheterocyclic Methane Scaffolds through Palladium‐Catalyzed Domino Cyclization
Author(s) -
Qi Hongbo,
Han Kaiming,
Chen Shufeng
Publication year - 2021
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202100242
Subject(s) - chemistry , benzofuran , domino , palladium , catalysis , cascade reaction , functional group , methane , combinatorial chemistry , cascade , medicinal chemistry , stereochemistry , organic chemistry , polymer , chromatography
Main observation and conclusion A convenient palladium‐catalyzed domino cyclization reaction for the construction of bis(benzofuranyl)methane scaffolds bearing an all‐carbon quaternary center has been described. In the cascade process, one C(sp 2 )—O bond, two C(sp 2 )—C(sp 3 ) bonds as well as two benzofuran rings are formed in a single synthetic sequence. The approach shows wide scope of substrates and good functional‐group tolerance. Moreover, this methodology is successfully extended to the synthesis of benzofuranyl methyl chromane derivatives.