Commiphoroids  G1 — G3 , H and I, Five Terpenoid Dimers as Extracellular Matrix Inhibitors from  Resina Commiphora | Zendy

Dong Lu | Zendy; Jiang JianBing | Zendy; Yan YongMing | Zendy; Wang ShuMei | Zendy; Cheng YongXian | Zendy

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Commiphoroids G1 — G3 , H and I, Five Terpenoid Dimers as Extracellular Matrix Inhibitors from Resina Commiphora

Author(s) -

Dong Lu,

Jiang JianBing,

Yan YongMing,

Wang ShuMei,

Cheng YongXian

Publication year - 2021

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.202100240

Subject(s) - chemistry , terpenoid , fibronectin , extracellular matrix , matrix (chemical analysis) , extracellular , stereochemistry , biochemistry , chromatography

Main observation and conclusion Commiphoroids G1—G3, H and I (1—5), five new terpenoid dimers were isolated from Resina Commiphora . Their structures and absolute configurations were determined by using spectroscopic, computational and crystallographic methods. Biological evaluation of these terpenoid dimers against renal fibrosis reveals that 5 inhibits extracellular matrix components including fibronectin and collagen I in a concentration‐dependent manner.

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