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Three‐Component Synthesis of 2‐Heteroaryl ‐3‐hydroxybenzo[ b ]‐thiophenes under Transition‐Metal‐Free Conditions
Author(s) -
Wang Dahan,
Xiao Fuhong,
Zhang Feng,
Deng GuoJun
Publication year - 2021
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202100238
Subject(s) - chemistry , benzaldehyde , thiophene , transition metal , catalysis , sulfur , reaction conditions , combinatorial chemistry , component (thermodynamics) , coupling reaction , stereochemistry , organic chemistry , physics , thermodynamics
Main observation and conclusion A convenient synthetic route to 2‐heteroaryl‐3‐hydroxybenzo[ b ]thiophene derivatives via K 2 CO 3 ‐promoted multicomponent cyclization between o ‐halogenated benzaldehyde, 2‐methylquinolines and sulfur powder has been demonstrated. This reaction is performed smoothly under simple conditions to give the corresponding products in moderate to good yields. The resultant 3‐hydroxybenzo[ b ]thiophenes have been proved to be versatile building blocks in a range of transition‐metal‐catalyzed cross‐coupling reactions.
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