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Uncommon Polycyclic Merosesquiterpenoids and Asteriscanoids from the Hainan Soft Coral Sinularia humesi †
Author(s) -
Chen ZiHui,
Yao LiGong,
Wu Qihao,
Guo YueWei
Publication year - 2021
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202100236
Subject(s) - chemistry , coral , enantiomer , stereochemistry , high resolution , ecology , remote sensing , biology , geology
Main observation and conclusion A rare highly fused racemic merosesquiterpenoid, 9‐ epi ‐verrubenzospirolactone (1), six new asteriscane‐type sesquiterpenoids, sinuhumesins A—F (4—9), and two related known ones (10 and 11) were isolated from Hainan soft coral Sinularia humesi . Compound 1 was further separated by chiral HPLC resolution to one pair of enantiomers [(+)‐1 and (–)‐1], respectively. The full structures of the new compounds were unambiguously determined by extensive spectroscopic analysis, chemical computation approaches, modified Mosher ' s method and/or X‐ray diffraction analysis, as well as comparison with previously reported data of related model compounds.