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Electrochemical Selective Oxidative Synthesis of Diversified Sulfur Heterocycles from β‐Ketothioamides
Author(s) -
Wen LiRong,
Wang NingNing,
Du WuBo,
Zhu MingZhe,
Pan Chao,
Zhang LinBao,
Li Ming
Publication year - 2021
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202100132
Subject(s) - chemistry , sulfur , electrosynthesis , dabco , electrochemistry , combinatorial chemistry , octane , transformation (genetics) , solvent , organic chemistry , electrode , biochemistry , gene
Main observation and conclusion A general and practical protocol for the construction of diversified sulfur heterocycles has been described through organic electrosynthesis means. In undivided cell, dihydrothiophenes, thiazolines and 1,4‐dithiines could be easily generated from various available β‐ketothioamides under metal‐free and external oxidant‐free conditions. The transformation underwent smoothly under mild conditions and could be easily scaled‐up. Moreover, different sulfur heterocycles were generated through varying solvent and 1,4‐diazabicyclo[2.2.2]octane (DABCO) could enable the hydrogen atom transfer (HAT) process of this transformation.