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Clerodenoids A—F: C‐ring Aromatized and/or Rearranged Abietane Diterpenoids from Clerodendrum chinense var. simplex
Author(s) -
Qi Jingjing,
Zhang Yan,
Liu Qunfang,
Liu Hongchun,
Fan Yaoyue,
Yue Jianmin
Publication year - 2021
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202100117
Subject(s) - abietane , chemistry , ring (chemistry) , stereochemistry , diterpene , organic chemistry
Main observation and conclusion As part of our continuing efforts toward the discovery of the biologically active diterpenoids from medicinal plants, six new C‐ring aromatized abietane diterpenoids, clerodenoids A—F (1—6), were isolated from Clerodendrum chinense . These C‐ring aromatized compounds mainly belonged to the rearranged abietane skeletons of 17(15→16)‐ abeo ‐abietane (2—4) and 17(15→16), 18(4→3)‐ diabeo ‐abietane (5 and 6). Their structures were elucidated by extensive spectroscopic data, X‐ray crystallography, and ECD calculation. Compounds 5 and 6 displayed strong antiproliferative activities against A549 and HL‐60 cell lines.