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Uncommon Bis‐quinolizidine Alkaloids from the Hainan Sponge Neopetrosia chaliniformi s
Author(s) -
Chen Bao,
Huan XiaJuan,
Miao ZeHong,
Voogd Nicole J.,
Gu YuCheng,
Wang ChangYun,
Guo YueWei,
Li XuWen
Publication year - 2021
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202100091
Subject(s) - quinolizidine , chemistry , sponge , stereochemistry , cytotoxicity , bioassay , alkaloid , botany , ecology , biochemistry , in vitro , biology
Main observation and conclusion Two new bis‐quinolizidine alkaloids, neopetrosiasins A (1) and B (2), possessing cis ‐ and trans ‐quinolizidine nuclei, one known related analogue petrosin (3) and three known xestospongins (4—6), were isolated from the South China Sea sponge Neopetrosia chaliniformis . The structures of new compounds were unambiguously determined by extensive spectroscopic and single‐crystal X‐ray analyses. In bioassay, compounds 4—6 exhibited moderate cytotoxicity against several human cancer cells.