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Lewis Acid Enables Ketone Phosphorylation: Synthesis of Alkenyl Phosphonates
Author(s) -
Wei XiaoHong,
Bai ChunYuan,
Zhao LianBiao,
Zhang Ping,
Li ZhenHua,
Wang YanBin,
Su Qiong
Publication year - 2021
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202100083
Subject(s) - chemistry , ketone , lewis acids and bases , dehydration , organic chemistry , sequence (biology) , reaction conditions , combinatorial chemistry , catalysis , biochemistry
Main observation and conclusion An efficient Lewis acid enabled ketones phosphonylation to synthesize vinylphosphonates has been developed. This method relays on ketone hydrophosphonylation/α‐hydroxy phosphonates unimolecular elimination (E1) dehydration cascade reaction sequence. Various C—P bond formation products were obtained in moderate to excellent yields with water as the only byproduct in the reaction.