Lewis Acid Enables Ketone Phosphorylation: Synthesis of Alkenyl Phosphonates | Zendy

Wei XiaoHong | Zendy; Bai ChunYuan | Zendy; Zhao LianBiao | Zendy; Zhang Ping | Zendy; Li ZhenHua | Zendy; Wang YanBin | Zendy; Su Qiong | Zendy

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Lewis Acid Enables Ketone Phosphorylation: Synthesis of Alkenyl Phosphonates

Author(s) -

Wei XiaoHong,

Bai ChunYuan,

Zhao LianBiao,

Zhang Ping,

Li ZhenHua,

Wang YanBin,

Su Qiong

Publication year - 2021

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.202100083

Subject(s) - chemistry , ketone , lewis acids and bases , dehydration , organic chemistry , sequence (biology) , reaction conditions , combinatorial chemistry , catalysis , biochemistry

Main observation and conclusion An efficient Lewis acid enabled ketones phosphonylation to synthesize vinylphosphonates has been developed. This method relays on ketone hydrophosphonylation/α‐hydroxy phosphonates unimolecular elimination (E1) dehydration cascade reaction sequence. Various C—P bond formation products were obtained in moderate to excellent yields with water as the only byproduct in the reaction.

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