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Publication year - 2020
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202090024
Subject(s) - chemistry , stereoselectivity , benzofuran , yield (engineering) , combinatorial chemistry , optically active , catalysis , cover (algebra) , stereochemistry , organic chemistry , mechanical engineering , materials science , engineering , metallurgy
Development of efficient catalytic asymmetric synthesis of chiral seven‐membered nitrogen‐containing heterocycles has been great important because their occurrence in a great number of pharmaceuticals and natural compounds. This work developed a Pd‐catalyzed asymmetric aromative [4+3]‐cyclization reaction of amino‐trimethylenemethanes (TMM, 1,3‐dipoles) with fused 1‐azadienes, which enables access to synthetically important and biologically active benzofuran fused azepines and indeno‐azepines in excellent efficiency and stereoselectivity (up to 95% yield, 99% ee, >19 : 1 dr). More details are discussed in the article by Deng and Shao et al . on page 151 ‐ 157.