Premium
Recent Advances in Nanopore Sensing †
Author(s) -
Cui Mengjie,
Ge Yaxian,
Zhuge Xiao,
Zhou Xin,
Xi Dongmei,
Zhang Shusheng
Publication year - 2021
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202000721
Subject(s) - nanopore , biomolecule , chemistry , nanotechnology , molecule , nanopore sequencing , dna , dna sequencing , biochemistry , materials science , organic chemistry
Nanopore sensing is developing into a powerful label‐free approach to investigate the features of biomolecules at the single‐molecule level. When a charged molecule is captured within a nanopore, it modulates the ionic current, which can be recorded in real time to reveal the properties of the target molecule. To date, nanopores have been used to sense a variety of analytes, including DNA, RNA, proteins, enzymes, small molecules, cancer cells, and metal ions, and can also provide information on biomolecular structures. In this review, we highlight the progress made in nanopore sensing over the past five years (2016—2020), and provide an outlook on future developments and directions in the field