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Synthesis of 3‐Methylthioindoles via Intramolecular Cyclization of 2‐Alkynylanilines Mediated by DMSO / DMSO ‐ d 6 and SOCl 2
Author(s) -
Li Xuemin,
Zhang Beibei,
Zhang Jingran,
Wang Xi,
Zhang Dongke,
Du Yunfei,
Zhao Kang
Publication year - 2021
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202000701
Subject(s) - chemistry , moiety , intramolecular force , indole test , combinatorial chemistry , stereochemistry
Main observation and conclusion The intramolecular cyclization of 2‐alkynylanilines mediated by DMSO/SOCl 2 was found to afford biologically interesting 3‐methylthioindoles, which are rarely obtained by the exiting methods. DMSO could also be replaced with its deuterated counterpart, enabling the method applicable to the construction of indole skeleton bearing a SCD 3 moiety at its 3‐position.