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Monoterpenoid Indole Alkaloids with Promoting Neurite Growth from Tabernaemontana divaricata
Author(s) -
Deng Yan,
Yu Yang,
Shi BaoBao,
Bao MeiFen,
Zhao SiMeng,
Cai XiangHai
Publication year - 2021
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202000656
Subject(s) - chemistry , aspidosperma , alkaloid , indole test , indole alkaloid , apocynaceae , stereochemistry , phytochemical , aporphine , enantiomer , neurite , traditional medicine , biochemistry , in vitro , medicine
Main observation and conclusion Phytochemical investigations on Tabernaemontana divaricata led to the isolation of seven undescribed monoterpenoid indole alkaloids, taberdicatines A—G ( 1 — 7 ). Taberdicatines A—C might be derived from Aspidosperma ‐type alkaloid, less skeletal carbons in 1 — 2 and an additional carbon in 3 . Taberdicatines D—E ( 4 — 5 ) were attributed to Iboga alkaloids with enantiomeric skeleton, respectively. Alkaloid 3 could promote the neurite growth of mouse primary cortical neurons at the concentration of 5 μmol/L.
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