One‐Pot  Synthesis of Polysubstituted Pyrroles  via  Sequential Ketenimine Formation/Ag(I)‐Catalyzed Alkyne Cycloisomerisation Starting from Ylide Adducts | Zendy

Xiong Jun | Zendy; Mu ZhiYing | Zendy; Yao Gang | Zendy; Zhang JiaAn | Zendy; Feng QiXun | Zendy; He HuiTing | Zendy; Pang YongLong | Zendy; Shi Hang | Zendy; Ding MingWu | Zendy

Premium

One‐Pot Synthesis of Polysubstituted Pyrroles via Sequential Ketenimine Formation/Ag(I)‐Catalyzed Alkyne Cycloisomerisation Starting from Ylide Adducts

Author(s) -

Xiong Jun,

Mu ZhiYing,

Yao Gang,

Zhang JiaAn,

Feng QiXun,

He HuiTing,

Pang YongLong,

Shi Hang,

Ding MingWu

Publication year - 2021

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.202000639

Subject(s) - ketenimine , chemistry , ylide , alkyne , isomerization , phosphorane , catalysis , adduct , medicinal chemistry , organic chemistry , combinatorial chemistry

Main observation and conclusion A simple one pot synthesis of polysubstituted pyrroles via ketenimine formation/Ag(I)‐catalyzed alkyne cycloisomerisation has been developed. The easily accessible phosphorane ylide derivatives reacted with isocyanates, producing highly active ketenimines that were then treated with amines, which afforded substituted pyrroles by a 5‐ exo ‐ dig cyclization/isomerization in the presence of a Ag(I) catalyst in good overall yields.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research