Phosphinic Acid/ NaI  Mediated Reductive Cyclization Approach for Accessing the   L ‐1‐Deoxynojirimycin  Using a  Two‐Component Three‐Centered  ( 2C3C ) Ugi Type Reaction | Zendy

Azad Chandra S | Zendy; Shukla Pratibha | Zendy; Olson Mark A | Zendy; Narula Anudeep K | Zendy

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Phosphinic Acid/ NaI Mediated Reductive Cyclization Approach for Accessing the L ‐1‐Deoxynojirimycin Using a Two‐Component Three‐Centered ( 2C3C ) Ugi Type Reaction

Author(s) -

Azad Chandra S,

Shukla Pratibha,

Olson Mark A,

Narula Anudeep K

Publication year - 2021

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.202000634

Subject(s) - chemistry , component (thermodynamics) , combinatorial chemistry , stereochemistry , thermodynamics , physics

Main observation and conclusion A catalytic two‐component three‐centered (2C3C) Ugi‐type reaction was developed for the synthesis of L ‐1‐deoxynojirimycin (DNJ) isomers using a chiron approach. This new and quite mild catalytic system, comprised of phenylphosphinic acid/NaI, was used to synthesize both the L ‐ allo ‐DNJ and L ‐ altro ‐DNJ in high yield.

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