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Awakening Sleeping Beauty: Vinyl Esters for Macrolactonization
Author(s) -
Song Qi,
Kong Luyao,
Zhu Lili,
Hong Ran,
Huang ShaHua
Publication year - 2021
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202000571
Subject(s) - chemistry , racemization , warrant , beauty , combinatorial chemistry , molecule , organic chemistry , nanotechnology , epistemology , philosophy , financial economics , economics , materials science
Macrolactones play a critical role in pharmaceuticals and agrochemicals. Numerous efforts have been devoted to developing synthetic methods for them. We highlighted a recent progress for building macrocycles (≥ 12‐membered) via bench‐stable vinyl ester (VE) intermediates, which have been underdeveloped for half century. These methods are mild and racemization‐free and warrant wide recognition in macrocyclization as the key step in complex molecule synthesis.