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Catalytic Benzylation Reactions: From C—H Bond Activation to C—N Bond Activation
Author(s) -
Jiang Tianxiao,
Liu Hongchi,
Zhang Haocheng,
Huang Hanmin
Publication year - 2021
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202000567
Subject(s) - chemistry , catalysis , medicinal chemistry , organic chemistry
Transition‐metal mediated activation of inert chemical bonds is an ongoing topic in homogeneous catalysis. In view of the abundance and accessibility of alkylarenes and benzylamines, the use of them as benzyl source in catalytic benzylation reactions via benzylic C—H and C—N bond activation is highly desirable. Indeed, compared with the traditional approaches with benzyl halide as the substrates, benzylation reactions via C—H and C—N bond cleavage provide more efficient, atom‐economic strategies to access myriads of synthetically important molecules. In this account, our group's efforts on catalytic benzylation reactions via directed C—H activation, nondirected C—H activation and C—N bond activation are summarized. What is the most favorite and original chemistry developed in your research group? Palladium‐catalyzed aminal chemistry. How do you supervise your students? Discuss with my students and encourage them to think about where the scientific problem is. What is the most important personality for scientific research? Honesty, curiosity and passion. What are your hobbies? Reading and playing badminton. Who influences you mostly in your life? My parents, who always inspire me to go forward. What is your favorite journal(s)? Journals that fairly review the manuscripts and publish inspiring, innovative research results.