Synthesis of  3‐Methylthio ‐benzo[ b ]furans/Thiophenes  via  Intramolecular Cyclization of  2‐Alkynylanisoles /Sulfides Mediated by  DMSO / DMSO ‐ d  6  and  SOCl 2 | Zendy

Zhang Beibei | Zendy; Li Xiaoxian | Zendy; Li Xuemin | Zendy; Sun Fengxia | Zendy; Du Yunfei | Zendy

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Synthesis of 3‐Methylthio ‐benzo[ b ]furans/Thiophenes via Intramolecular Cyclization of 2‐Alkynylanisoles /Sulfides Mediated by DMSO / DMSO ‐ d 6 and SOCl 2

Author(s) -

Zhang Beibei,

Li Xiaoxian,

Li Xuemin,

Sun Fengxia,

Du Yunfei

Publication year - 2021

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.202000566

Subject(s) - chemistry , moiety , intramolecular force , solvent , medicinal chemistry , stereochemistry , sulfur , organic chemistry

Main observation and conclusion The reaction of 2‐alkynylanisoles/sulfides with SOCl 2 and DMSO was conducted to conveniently furnish the biologically interesting 3‐(methylthio)‐benzo[ b ]furans/thiophenes via intramolecular cyclization. DMSO acts as a solvent as well as a sulfur source and can also be replaced with DMSO‐ d 6 , enabling the incorporation of the SCD 3 moiety of DMSO‐ d 6 to the 3‐position of the heterocyclic frameworks.

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