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Synthesis of 3‐Methylthio ‐benzo[ b ]furans/Thiophenes via Intramolecular Cyclization of 2‐Alkynylanisoles /Sulfides Mediated by DMSO / DMSO ‐ d 6 and SOCl 2
Author(s) -
Zhang Beibei,
Li Xiaoxian,
Li Xuemin,
Sun Fengxia,
Du Yunfei
Publication year - 2021
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202000566
Subject(s) - chemistry , moiety , intramolecular force , solvent , medicinal chemistry , stereochemistry , sulfur , organic chemistry
Main observation and conclusion The reaction of 2‐alkynylanisoles/sulfides with SOCl 2 and DMSO was conducted to conveniently furnish the biologically interesting 3‐(methylthio)‐benzo[ b ]furans/thiophenes via intramolecular cyclization. DMSO acts as a solvent as well as a sulfur source and can also be replaced with DMSO‐ d 6 , enabling the incorporation of the SCD 3 moiety of DMSO‐ d 6 to the 3‐position of the heterocyclic frameworks.