Rh‐Catalyzed  Formal [3+2] Cyclization for the Synthesis of  5‐Aryl ‐2‐(quinolin‐2‐yl)oxazoles and Its Applications in Metal Ions Probes | Zendy

Zhou Tongtong | Zendy; He Xinwei | Zendy; Zuo Youpeng | Zendy; Wu Yuhao | Zendy; Hu Wangcheng | Zendy; Zhang Shiwen | Zendy; Duan Jiahui | Zendy; Shang Yongjia | Zendy

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Rh‐Catalyzed Formal [3+2] Cyclization for the Synthesis of 5‐Aryl ‐2‐(quinolin‐2‐yl)oxazoles and Its Applications in Metal Ions Probes

Author(s) -

Zhou Tongtong,

He Xinwei,

Zuo Youpeng,

Wu Yuhao,

Hu Wangcheng,

Zhang Shiwen,

Duan Jiahui,

Shang Yongjia

Publication year - 2021

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.202000454

Subject(s) - chemistry , oxazole , aryl , combinatorial chemistry , catalysis , rhodium , quinoline , medicinal chemistry , stereochemistry , organic chemistry , alkyl

Main observation and conclusion A facile and efficient strategy for the synthesis of 5‐aryl‐2‐(quinolin‐2‐yl)oxazoles via rhodium‐catalyzed formal [3+2] cyclization of 4‐aryl‐1‐tosyl‐1 H ‐1,2,3‐triazoles with quinoline‐2‐carbaldehydes has been described. The protocol employs mild conditions and offers good yields of diverse 2,5‐aryloxazole derivatives with a broad reaction scope. It is amenable to gram‐scale synthesis and easily transformation. Moreover, this 5‐aryl‐2‐(quinolin‐2‐yl)oxazole skeleton is indeed a new fluorophore and its applications in metal ions probes are also investigated and showed fluorescent responses to mercury ion.

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