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Current Understanding toward Isonitrile Group Biosynthesis and Mechanism
Author(s) -
Chen TzuYu,
Chen Jinfeng,
Tang Yijie,
Zhou Jiahai,
Guo Yisong,
Chang Weichen
Publication year - 2021
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202000448
Subject(s) - chemistry , mechanism (biology) , group (periodic table) , biosynthesis , combinatorial chemistry , biochemistry , organic chemistry , epistemology , gene , philosophy
Isonitrile group has been identified in many natural products. Due to the broad reactivity of N≡C triple bond, these natural products have valuable pharmaceutical potentials. This review summarizes the current biosynthetic pathways and the corresponding enzymes that are responsible for isonitrile‐containing natural product generation. Based on the strategies utilized, two fundamentally distinctive approaches are discussed. In addition, recent progress in elucidating isonitrile group formation mechanisms is also presented.