Premium
Enantioselective Synthesis of Tetrahydroquinolines via One‐Pot Cascade Biomimetic Reduction †
Author(s) -
Zhao ZiBiao,
Li Xiang,
Chen MuWang,
Wu Bo,
Zhou YongGui
Publication year - 2020
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202000409
Subject(s) - chemistry , enantioselective synthesis , cascade , ruthenium , quinoline , combinatorial chemistry , catalysis , biomimetic synthesis , reduction (mathematics) , organic chemistry , chromatography , geometry , mathematics
Summary of main observation and conclusion A novel and efficient protocol for the synthesis of chiral tetrahydroquinoline derivatives with excellent enantioselectivities and high yields has been developed through one‐pot cascade biomimetic reduction. The detailed reaction pathway includes the acid‐catalyzed and ruthenium‐catalyzed formation of aromatic quinoline intermediates and biomimetic asymmetric reduction.