Premium
Electrochemical Palladium‐Catalyzed Intramolecular C—H Amination of 2‐Amidobiaryls for Synthesis of Carbazoles
Author(s) -
Wang Qingqing,
Zhang Xiaojing,
Wang Pan,
Gao Xinlong,
Zhang Heng,
Lei Aiwen
Publication year - 2021
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202000407
Subject(s) - chemistry , amination , intramolecular force , catalysis , palladium , electrochemistry , combinatorial chemistry , coupling reaction , oxidative phosphorylation , reaction conditions , organic chemistry , biochemistry , electrode
Main observation and conclusion The synthesis of carbazoles based on the electrochemical Pd‐catalyzed intramolecular C—H amination of 2‐amidobiaryls through oxidative cross coupling has been achieved under mild reaction conditions. The reaction can be carried out in undivided cell without the addition of external chemical oxidant. Besides good functional group compatibility, the desired carbazoles can be scaled up and modified easily. Compared with previous methods, this protocol affords a simple and sustainable avenue for the construction of carbazoles.