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Synergistic Catalysis with Azomethine Ylides
Author(s) -
Wei Liang,
Wang ChunJiang
Publication year - 2021
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202000380
Subject(s) - chemistry , catalysis , azomethine ylide , combinatorial chemistry , synergistic catalysis , reaction conditions , molecule , organic chemistry , cycloaddition , 1,3 dipolar cycloaddition
Abstract Azomethine ylides are useful intermediates for the rapid construction of chiral N‐ containing compounds. However, its synthetic potential has not been fully developed due to the limited reaction models. In combination with synergistic catalysis and azomethine ylide chemistry, we have developed several types of novel catalytic system including Cu/Pd, Cu/Ir and PTC/Ir catalysis, which can convert readily‐available azomethine ylides to various high‐valued molecules such as unnatural α‐amino acids, homoallylic amines and N‐ heterocycles. Compared with the traditional mono‐catalysis, the synergistic catalyst system exhibits enhanced catalytic efficiency and chiral induction ability in many cases. In addition, we have demonstrated that these strategies could be applied in the construction of bioactive compounds and natural products.