Premium
Aryl Diazonium Salt‐Triggered Cyclization and Cycloaddition Reactions: Past, Present, and Future
Author(s) -
Zhang FaGuang,
Chen Zhen,
Cheung Chi Wai,
Ma JunAn
Publication year - 2020
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202000270
Subject(s) - chemistry , synthon , cycloaddition , aryl , annulation , the renaissance , combinatorial chemistry , salt (chemistry) , reactivity (psychology) , organic chemistry , chemical space , scope (computer science) , catalysis , drug discovery , medicine , art , alkyl , alternative medicine , pathology , art history , biochemistry , computer science , programming language
Aryl diazonium salts occupy a privileged role in synthetic chemistry owing to their ready availability and versatile reactivity. While their applications in accessing diversely functionalized arene derivatives via denitrogenation‐coupling and reduction/addition reactions have been well recognized by practitioners in both academia and industry, recent renaissance in chemical transformations of retaining the key N 2 ‐unit has emerged as a powerful technique to construct various N ‐heterocycles. This review covers the history and latest advances in cyclization and cycloaddition reactions using aryl diazonium salts as N 2 ‐annulation synthons. The scope, applications, and opportunities in exploring new chemical space by this sustainable strategy are summarized and discussed.