A Journey to  SPSiOL , a New Type of Chiral Ligand Scaffold | Zendy

Chen HongChao | Zendy; Chang Xin | Zendy

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A Journey to SPSiOL , a New Type of Chiral Ligand Scaffold

Author(s) -

Chen HongChao,

Chang Xin

Publication year - 2020

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.202000256

Subject(s) - chemistry , enantiopure drug , combinatorial chemistry , enantioselective synthesis , chiral ligand , catalysis , ligand (biochemistry) , scaffold , block (permutation group theory) , stereochemistry , organic chemistry , receptor , biochemistry , medicine , biomedical engineering , geometry , mathematics

We report the development of a class of chiral spirosilabiindane scaffolds via Rh‐catalyzed asymmetric double hydrosilation. Enantiopure SPSiOL (spirosilabiindane diol), a new type of chiral building block for preparation of various chiral ligands and catalysts, could be readily prepared on >10‐gram scale using this protocol.

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