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A Journey to SPSiOL , a New Type of Chiral Ligand Scaffold
Author(s) -
Chen HongChao,
Chang Xin
Publication year - 2020
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202000256
Subject(s) - chemistry , enantiopure drug , combinatorial chemistry , enantioselective synthesis , chiral ligand , catalysis , ligand (biochemistry) , scaffold , block (permutation group theory) , stereochemistry , organic chemistry , receptor , biochemistry , medicine , biomedical engineering , geometry , mathematics
We report the development of a class of chiral spirosilabiindane scaffolds via Rh‐catalyzed asymmetric double hydrosilation. Enantiopure SPSiOL (spirosilabiindane diol), a new type of chiral building block for preparation of various chiral ligands and catalysts, could be readily prepared on >10‐gram scale using this protocol.