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Trifluoromethylation of Alkyl Radicals: Breakthrough and Challenges †
Author(s) -
Zhu Lin,
Fang Yewen,
Li Chaozhong
Publication year - 2020
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202000095
Subject(s) - trifluoromethylation , chemistry , alkyl , radical , halide , organic chemistry , medicinal chemistry , trifluoromethyl
Trifluoromethylation of alkyl radicals is emerging as a powerful tool for C(sp 3 )–CF 3 bond formations. Based on the hypothesis of CF 3 group transfer from Cu(II)–CF 3 to alkyl radicals, a number of trifluoromethylation reactions have been developed, including trifluoromethylation of alkyl halides, decarboxylative trifluoromethylation of aliphatic carboxylic acids, C(sp 3 )–H trifluoromethylation, amino‐ and carbo‐trifluoromethylation of alkenes, etc . Challenges in this intriguing field are also discussed.