Premium
Trifluoromethylation of Alkyl Radicals: Breakthrough and Challenges †
Author(s) -
Zhu Lin,
Fang Yewen,
Li Chaozhong
Publication year - 2020
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202000095
Subject(s) - trifluoromethylation , chemistry , alkyl , radical , halide , organic chemistry , medicinal chemistry , trifluoromethyl
Trifluoromethylation of alkyl radicals is emerging as a powerful tool for C(sp 3 )–CF 3 bond formations. Based on the hypothesis of CF 3 group transfer from Cu(II)–CF 3 to alkyl radicals, a number of trifluoromethylation reactions have been developed, including trifluoromethylation of alkyl halides, decarboxylative trifluoromethylation of aliphatic carboxylic acids, C(sp 3 )–H trifluoromethylation, amino‐ and carbo‐trifluoromethylation of alkenes, etc . Challenges in this intriguing field are also discussed.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom