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Radical Heteroarylalkylation of Alkenes via Three‐Component Docking‐Migration Thioetherification Cascade
Author(s) -
Niu Tao,
Liu Jige,
Wu Xinxin,
Zhu Chen
Publication year - 2020
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202000088
Subject(s) - chemistry , cascade , alkene , reagent , alkyl , docking (animal) , combinatorial chemistry , compatibility (geochemistry) , stereochemistry , organic chemistry , catalysis , chemical engineering , medicine , nursing , chromatography , engineering
Summary of main observation and conclusion A novel, rational‐designed approach to access various heteroaryl‐substituted alkyl thioethers was developed via docking‐migration cascade process. By utilizing three components involving alkene, dual‐function reagent, and thioetherificating reagent, radical heteroarylalkylation of alkenes followed by thiolation of the alkyl radical intermediates proceeded smoothly, manifesting well compatibility of substrates and cascade transformations. Furthermore, this protocol also features mild conditions, broad substrate scope, and wide product diversity.