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Biomimetic Asymmetric Reduction of Quinazolinones with Chiral and Regenerable NAD (P)H Models
Author(s) -
Zhao ZiBiao,
Li Xiang,
Wu Bo,
Zhou YongGui
Publication year - 2020
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202000045
Subject(s) - chemistry , nad+ kinase , combinatorial chemistry , reduction (mathematics) , bromodomain , divalent , enantioselective synthesis , stereochemistry , biochemistry , organic chemistry , catalysis , enzyme , geometry , mathematics , acetylation , gene
Summary of main observation and conclusion A facile approach to chiral dihydroquinazolinone derivatives has been described via biomimetic asymmetric reduction of quinazolinones with chiral and regenerable NAD(P)H models. The utility of this method was demonstrated by a concise synthesis of the bromodomain protein divalent inhibitor.