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Synthesis and Insecticidal Evaluation of Novel Anthranilic Diamides Derivatives Containing 4‐Chlorine Substituted N ‐Pyridylpyrazole
Author(s) -
Li Huangong,
Zhao Yangyang,
Sun Pengwei,
Gao Li,
Li Yuxin,
Xiong Lixia,
Yang Na,
Zhou Sha,
Li Zhengming
Publication year - 2021
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202000013
Subject(s) - chemistry , diamondback moth , ryanodine receptor , chlorine , stereochemistry , calcium , receptor , plutella , biochemistry , larva , organic chemistry , botany , biology
Main observation and conclusion To search for potent insecticides targeting at ryanodine receptors (RyRs), a series of novel anthranilic diamides analogs containing 4‐chlorine N ‐pyridylpyrazole were designed and synthesized. Their insecticidal activities were evaluated and the preliminary structure‐activity relationships (SARs) were discussed. The insecticidal results showed that some of the compounds (8a—8h, 8m, 8n) exhibited good larvicidal activities against oriental armyworm at 2.5 mg·L –1 , and compound 8m possessed 60% insecticidal activity at 0.5 mg·L –1 . For diamondback moth, 8m exhibited better activity than Chlorantraniliprole at a hundred fold preference. The calcium imaging technique experiment results suggested that compound 8m could increase the intracellular [Ca 2+ ] i . With the neurons preincubated experiment, the results confirmed that the target of this series of compounds could be RyRs in the central larvae neurons of oriental armyworm. The results indicated that compound 8m could respond as a potential modulator of the insect ryanodine receptor.