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A Novel Route to Synthesize N, N ‐Dimethyl Arylmethylamines from Aryl Aldehydes, Hexamethylenetetramine and Hydrogen †
Author(s) -
Ke Zhengang,
Yu Bo,
Wu Yunyan,
Zhao Yanfei,
Yang Peng,
Guo Shien,
Liu Zhimin
Publication year - 2020
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.202000004
Subject(s) - hexamethylenetetramine , dimethylamine , chemistry , aryl , hydrogen , combinatorial chemistry , organic chemistry , alkyl
Summary of main observation and conclusion Developing simple and green routes to access valuable chemicals is of significance. Herein, we present a green and novel route to synthesize N,N‐ dimethyl arylmethylamines (DAMAs) from hexamethylenetetramine (HMTA) and aryl aldehydes in the presence of hydrogen, and a series of DAMAs can be obtained in good yields. This approach opens the precedent for HMTA as N,N ‐dimethylamine source to synthesize chemicals with N,N ‐dimethylamine group, which has promising applications for N ‐containing chemicals synthesis.