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Asymmetric Intramolecular Hydroalkoxylation of Unactivated Alkenes Catalyzed by Chiral N‐ Triflyl Phosphoramide and TiCl 4 †
Author(s) -
Zhao Pengyuan,
Cheng Aolin,
Wang Xinxu,
Ma Jiguo,
Zhao Guoqing,
Li Yingkun,
Zhang Yi,
Zhao Baoguo
Publication year - 2020
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201900544
Subject(s) - chemistry , intramolecular force , catalysis , tetrahydrofuran , medicinal chemistry , enantioselective synthesis , organic chemistry , solvent
Summary of main observation and conclusion By using a combination of a chiral N ‐triflyl phosphoramide and TiCl 4 as the catalyst, a new process for asymmetric intramolecular hydroalkoxylation of unactivated alkenes was developed, producing various chiral tetrahydrofuran derivatives in 51%—99% yields with 30%—71% ee's.
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